IL-3 Polyclonal Antibody
Price:
Size:
100 μL
25 μL
- 宿主： Rabbit
- 反应性： Human
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC: Human tonsil |
| Dilution | IHC 1:500-1:1000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant Mouse IL-3 protein expressed by E.coli |
| Abbre | IL-3 |
| Synonyms | Interleukin, Hematopoietic Growth Factor, Interleukin-3, Mast Cell Growth Factor, MCGF, MCSF, MULTI-CSF, Multipotential Colony-Stimulating Factor, P-Cell Stimulating Factor, P-Cell-Stimulating Factor, Csfmu, Il-3, Il3 |
| Swissprot | |
| Cellular Localization | Secreted |
| Tissue Specificity | Activated T-cells, mast cells, natural killer cells. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Background | IL3 (Interleukin 3) is a Protein Coding gene. Diseases associated with IL3 include Hematologic Cancer and Allergic Disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation. Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK. |
Immunohistochemistry of paraffin-embedded Human tonsil using IL-3 Polyclonal Antibody at dilution of 1:1200.
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