IL-6R alpha Polyclonal Antibody(Capture/Detector)
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- 宿主： Goat
- 反应性： Mouse
- 应用性： ELISA Capture/Detector
| Verified Samples |
Verified Samples in ELISA: Recombinant Mouse IL-6R alpha protein, Mouse serum, Mouse plasma |
| Dilution | ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Polyclonal |
| Isotype | Goat IgG |
| Immunogen | Recombinant Mouse IL-6R alpha ra Protein expressed by Mammalian |
| Abbre | IL-6R alpha |
| Synonyms | InterLeukin-6 receptor subunit aLpha, IL-6 receptor subunit aLpha, IL-6R subunit aLpha, IL-6R-aLpha, IL-6RA, IL-6R 1 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Background | Part of the receptor for interleukin 6. Binds to Il6 with low affinity,but does not transduce a signal. Signal activation necessitate an association with Il6ST. Activation leads to the regulation of the immune response,acute-phase reactions and hematopoiesis. The interaction with membrane-bound Il6R and Il6ST stimulates 'classic signaling',the restricted expression of the Il6R limits classic Il6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of Il6 and soluble Il6R to Il6ST stimulates 'trans-signaling'. Alternatively,'cluster signaling' occurs when membrane-bound Il6:Il6R complexes on transmitter cells activate Il6ST receptors on neighboring receiver cells. |
