Ki67 Monoclonal Antibody
Price:
Size:
100 μL
25 μL
- 宿主： Mouse
- 反应性： Human
- 应用性： IHC;IF
| Verified Samples |
Verified Samples in IHC: Human Gastric cancer, Human Ovarian cancer Verified Samples in IF: HeLa |
| Dilution | IHC 1:500-1:1000, IF 1:200-1:400 |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Immunogen | Recombinant human Ki67 protein expressed by E.coli |
| Abbre | Ki67 |
| Synonyms | MIB, MKI, marker of proliferation Ki, Proliferation marker protein Ki, Antigen identified by monoclonal antibody Ki, PPP1R, MKI67, KIA, MIB-, MIB-1, PPP1R105, marker of proliferation Ki-67, Ki67, Antigen identified by monoclonal antibody Ki-67, Antigen Ki67, Antigen KI-67, Proliferation marker protein Ki-67, Antigen identified by monoclonal Ki 67, Antigen identified by monoclonal Ki-67, MIB 1, Proliferation related Ki 67 antigen, Protein phosphatase 1 regulatory subunit 105, RP11-380J17.2 |
| Swissprot | |
| Cellular Localization | Nucleus |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Protein A/G Purification |
| Research Areas | Cell Biology, Neuroscience, Tags & Cell Markers, Cancer |
| Clone No. | 3B7 |
| Conjugation | Unconjugated |
| Background | Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). |
Immunohistochemistry of paraffin-embedded Human Gastric cancer using Ki67 Monoclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human Ovarian cancer using Ki67 Monoclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of HeLa cells using Ki67 Monoclonal Antibody at dilution of 1:500.
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