Osteoprotegerin/TNFRSF11B Monoclonal Antibody(Capture)
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- 宿主： Rat
- 反应性： Human
- 应用性： ELISA Capture
| Verified Samples |
Verified Samples in ELISA: Recombinant Human Osteoprotegerin/TNFRSF11B protein, Human serum, Human plasma |
| Dilution | ELISA Capture 2-8 μg/mL |
| Clonality | Monoclonal |
| Isotype | Rat IgG1 |
| Immunogen | Recombinant Human Osteoprotegerin/TNFRSF11B protein expressed by Mammalian |
| Abbre | Osteoprotegerin/TNFRSF11B |
| Synonyms | Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, OCIF, OPG |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Cardiovascular, Immunology, Signal Transduction, Metabolism |
| Clone No. | 5G9 |
| Conjugation | Unconjugated |
| Background | TNFRSF11B is a secreted protein; containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL; TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes; and a key regulator of inflammation; innate immunity; and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells; blocks the RANKL-RANK ligand interaction between |
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