PD-L1 Monoclonal Antibody(Detector)
Price:
- 宿主： Mouse
- 反应性： Human
- 应用性： ELISA Detector
| Verified Samples |
Verified Samples in ELISA: Recombinant Human PD-L1 protein, Human serum, Human plasma |
| Dilution | ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Immunogen | Recombinant Human PD-L1 L1 protein expressed by Mammalian |
| Abbre | PD-L1 |
| Synonyms | CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, Programmed ceLL death 1 Ligand 1, B7 homoLog 1, PDCD1 Ligand 1, Programmed death Ligand 1, hPD-L1 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Immunology, Cancer |
| Clone No. | 5A7 |
| Conjugation | Unconjugated |
| Background | Plays a critical role in induction and maintenance of immune tolerance to self.As a ligand for the inhibitory receptor PDCD1/PD-1,modulates the activation threshold of T-cells and limits T-cell effector response.Through a yet unknown activating receptor,may costimulate T-cell subsets that predominantly produce interleukin-10 (Il10).Can also act as a transcription coactivator: in response to hypoxia,translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC,leading to pyroptosis.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system,thereby facilitating tumor survival.The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTls) effector function.
The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response,providing a rationale for cancer immunotherapy. |
| AN001380P | PD-L1 Monoclonal Antibody(Capture) | 100 μg , 25 μg , 1 mg |
