PE Anti-Mouse Foxp3 Antibody[3G3]
![PE Anti-Mouse Foxp3 Antibody[3G3]](http://files.elabscience.cn/assets/images/loading.png)
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- 应用性： ICFCM
- 亚型： Mouse IgG1, κ
- 宿主： Mouse
| Alternate Names | Forkhead box protein P3, Foxp3, IPEX, JM2 |
| Cellular Localization |
Nucleus
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| Clone No | |
| Isotype | Mouse IgG1, κ |
| Leadtime |
咨询
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| Background |
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
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| Abbre | Foxp3 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype Control | |
| Applications | |
| Form | Liquid |
| Concentration | 5 μL/Test |
| Conjugation | PE |
| Conjugation Information | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping |
冰袋 |
| Gene ID |
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| E-CK-A105 | 10×ACK Lysis Buffer | 500 mL , 200 mL , 100 mL |
| E-CK-A107 | Cell Staining Buffer | 500 mL , 200 mL , 100 mL |
| E-CK-A108 | Foxp3/Transcription Factor Staining Kit | 20 Assays |
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