PE/Cyanine7 Anti-Mouse CD206/MMR Antibody[C068C2]
![PE/Cyanine7 Anti-Mouse CD206/MMR Antibody[C068C2]](http://files.elabscience.cn/assets/images/loading.png)
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- 应用性： FCM;ICFCM
- 亚型： Rat IgG2a, κ
- 宿主： Rat
| Alternate Names | MMR, MR, MRC1, macrophage mannose receptor, mannose receptor |
| Cellular Localization |
Membrane;Endosome
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| Clone No | |
| Isotype | Rat IgG2a, κ |
| Leadtime |
咨询
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| Background |
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
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| Abbre | CD206 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype Control | |
| Applications | |
| Form | Liquid |
| Concentration | 5 μL/Test |
| Conjugation | PE/Cyanine 7 |
| Conjugation Information | PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping |
冰袋 |
| Gene ID |
-
IFN-γ enhances the antitumor activity of attenuated salmonella-mediated cancer immunotherapy by increasing M1 macrophage and CD4 and CD8 T cell counts and decreasing neutrophil counts
IF: 6.064Journal： Frontiers in Bioengineering and Biotechnology (2022)Reactivity：MouseSample Type：CT26 cell xenografts -
Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment
IF: 5.249
| E-CK-A105 | 10×ACK Lysis Buffer | 500 mL , 200 mL , 100 mL |
| E-CK-A107 | Cell Staining Buffer | 500 mL , 200 mL , 100 mL |
| E-CK-A109 | Intracellular Fixation/Permeabilization Buffer Kit | 500 Assays , 100 Assays , 50 Assays |
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