Purified Anti-Human CD74 Antibody[LN2]-Elabscience伊莱瑞特【官网】

Purified Anti-Human CD74 Antibody[LN2]

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货号：E-AB-F1072A
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说明书

说明书

Price: ¥1230.00 ¥500.00

Size:

100 μg 25 μg

应用性： FCM
亚型： Mouse IgG1, κ
宿主： Mouse

Alternate Names	CD74, DHLAG, HLA class II histocompatibility antigen gamma chain, Ia antigen-associated invariant chain, Ii, p33
Clone No	LN2
Isotype	Mouse IgG1, κ
Leadtime	咨询
Verified Samples	Verified Samples in FCM: Human peripheral blood lymphocytes
Dilution	FCM 2 μg/mL(1×10⁵-5×10⁵ cells)
Background	CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
Immunogen	Recombinant Human CD74 protein
Abbre	CD74
Swissprot	P04233
Host	Mouse
Reactivity	Human
Clonality	Monoclonal
Purification Method	>98%, Protein A/G purified
Applications	FCM
Research Areas	Immunology
Concentration	≥ 1 mg/mL
Conjugation	Unconjugated
Storage Buffer	PBS, pH 7.2. Contains 0.05% proclin 300.
Storage	Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Expiration Date	12个月
Shipping	Ice bag

Human peripheral blood lymphocytes were stained with 0.2 μg Purified Anti-Human CD74 Antibody[LN2] (Right) and 0.2 μg Mouse IgG1, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD19 PE-conjugated Monoclonal Antibody.

Exosome from hypoxia-conditioned apical papilla stem cells delivers JAG1 to accelerate angiogenesis in vitro through Notch signal

IF: 2.600

Journal： TISSUE & CELL (2023)

DOI：10.1016/j.tice.2023.102197

PMID：37595532

Reactivity：Human

E-AB-F1072B	Biotin Anti-Human CD74 Antibody[LN2]	100μg , 25μg
E-AB-F1072C	FITC Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072D	PE Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072E	APC Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072G	PE/Cyanine5 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072H	PE/Cyanine7 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072I	PE/Cyanine5.5 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072J	PerCP/Cyanine5.5 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072L	Elab Fluor® 488 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072M	Elab Fluor® 647 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2
E-AB-F1072P	PE/Elab Fluor® 594 Anti-Human CD74 Antibody[LN2]	100Tests , 20Tests , 100Tests×2