Recombinant Human B7 Homolog 4/B7-H4/VTCN1 (C-Fc-Avi) Biotinylated-Elabscience伊莱瑞特【官网】

Recombinant Human B7 Homolog 4/B7-H4/VTCN1 (C-Fc-Avi) Biotinylated

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货号：PKSH033983
说明书

说明书

Recombinant Human B7 Homolog 4/B7-H4/VTCN1 (C-Fc-Avi) Biotinylated

Price: ¥7560.00 ¥2786.00

Size:

100 μg 20 μg

表达系统： HEK293 Cells
蛋白编码： Q7Z7D3
应用性： ELISA

别称	B7-H4;B7H4T-cell costimulatory molecule B7x;B7S1;B7S1VCTN1;B7XPRO1291;B7h.5;B7x;FLJ22418;Immune costimulatory protein B7-H4;Protein B7S1;T cell costimulatory molecule B7x;V-set domain containing T cell activation inhibitor 1;V-set domain-containing ;Vtcn1
表达系统	HEK293 Cells
序列	Phe29-Ala258
蛋白编码	Q7Z7D3
种属	Human
计算分子量	54.1 kDa
表观分子量	70-95 kDa
标签	C-Fc-Avi
生物活性	Immobilized Anti-Human B7-H4 mAb at 2μg/ml (100 μl/well) can bind Biotinylated Human B7-H4-Fc-Avi. The ED50 of Biotinylated Human B7-H4-Fc-Avi is 0.23 ng/ml.
纯度	> 95 % as determined by reducing SDS-PAGE.
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method.
保存条件	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输条件	This product is provided as lyophilized powder which is shipped with ice packs.
制剂	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
复溶方法	Please refer to the printed manual for detailed information.
背景	B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.

> 95 % as determined by reducing SDS-PAGE.

Immobilized Anti-Human B7-H4 mAb at 2μg/ml (100 μl/well) can bind Biotinylated Human B7-H4-Fc-Avi. The ED50 of Biotinylated Human B7-H4-Fc-Avi is 0.23 ng/ml.