TRANCE/RANKL/TNFSF11 Monoclonal Antibody(Capture/Detector)
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- 宿主： Mouse
- 反应性： Human
- 应用性： ELISA Capture/Detector
| Verified Samples |
Verified Samples in ELISA: Recombinant Human TRANCE/RANKL/TNFSF11 protein, Human serum, Human plasma |
| Dilution | ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Immunogen | Recombinant Human TRANCE/RANKL/TNFSF11 protein expressed by E.coli |
| Abbre | TRANCE/RANKL/TNFSF11 |
| Synonyms | CD254, TNFSF11, OPGL, RANKL, TRANCE, Tumor necrosis factor Ligand superfamiLy member 11, OsteocLast differentiation factor (ODF), Osteoprotegerin Ligand (OPGL), Receptor activator of nucLear factor kappa-B Ligand (RANKL), TNF-reLated activation-induced cytokine (TRANCE) |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Immunology, Cardiovascular |
| Clone No. | 4D4 |
| Conjugation | Unconjugated |
| Background | Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells,chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1,which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation,in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. |
