BAX Monoclonal Antibody
Price:
Size:
120 μL
60 μL
20 μL
- 宿主： Mouse
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC-p
| Verified Samples |
Verified Samples in WB: Hela, C2C12, PC12 Verified Samples in IHC: Human breast carcinoma, Mouse kidney |
| Dilution | WB 1:1000-2000, IHC 1:100-200 |
| Clonality | Monoclonal |
| Isotype | IgG |
| Immunogen | Synthetic Peptide of Bax |
| Abbre | BAX |
| Synonyms | Apoptosis regulator BAX, BAX, BAXA, BCL2 associated X protein, BCL2 associated X protein omega, BCL2 associated X protein transcript variant delta2, BCL2L4, Bax-protein, Baxdelta2G9, Baxdelta2G9omega, Baxdelta2omega, Bcl-2-like protein 4, Bcl2-L-4, membrane isofor |
| Swissprot | |
| Observed MW | 20 kDa |
| Cellular Localization | Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. |
| Tissue Specificity | Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology, Metabolism |
| Clone No. | 1D8 |
| Conjugation | Unconjugated |
| Background | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. |
Western Blot analysis of 1) Hela, 2) C2C12, 3) PC-12 cells using Bax Monoclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using Bax Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Mouse kidney tissue using Bax Monoclonal Antibody at dilution of 1:200.
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Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model
IF: 2.245Journal： CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2022)Reactivity：RatSample Type：cardiac tissue,renal tissue -
Cysteamine Attenuate Intestinal Reperfusion Injury Induced by Occlusion of Mesenteric Artery by Enhancing Intracellular Thiol Activities
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Lysophosphatidic Acid Alters The Expression of Apoptosis Related Genes and miR-22 in Cultured and Autotransplanted Ovaries
IF: 2.479Journal： Cell Journal (2021)Reactivity：MouseSample Type：ovarian tissue -
Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line
Journal： International Journal of Molecular and Cellular Medicine (2021)Reactivity：Human -
The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines
IF: 2.479Journal： BMC Complementary and Alternative Medicine (2019)PMID：31830975Reactivity：HumanSample Type：Cell culture supernatant
| E-AB-1001 | Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1024 | Goat Anti-Mouse IgG(H+L)(Biotin conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-IR-R304A | Western Blot Detection Kit | 50 Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50 Assays |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 50 mL , 18 mL , 6 mL , 3 mL |
| E-IR-R220 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10 mL , 3 mL |
| E-IR-R221 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10 mL , 3 mL |
| E-AB-1196 | HRP-Goat Anti-Mouse IgG(H+L) preadsorbed | 500 μL , 120 μL , 1 mL |
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