BCL2 Monoclonal Antibody-Elabscience伊莱瑞特【官网】

BCL2 Monoclonal Antibody

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货号：E-AB-22004
文献（23）
说明书

说明书

Price: ¥2310.00 ¥1420.00 ¥580.00

Size:

120 μL 60 μL 20 μL

宿主： Mouse
反应性： Human
应用性： WB

Verified Samples	Verified Samples in WB: Hela Verified Samples in IHC: Human tonsil
Dilution	WB 1:1000-2000
Clonality	Monoclonal
Isotype	IgG
Immunogen	Synthetic Peptide
Abbre	Bcl-2
Synonyms	2, AW986256, Apoptosis regulator Bcl 2, Apoptosis regulator Bcl-2, Apoptosis regulator Bcl2, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, B-cell, BCL2, Bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, Oncogene B-cell leukemia 2, PPP1R50
Swissprot	P10415
Calculated MW	26 kDa
Observed MW	26 kDa
Cellular Localization	Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Tissue Specificity	Expressed in a variety of tissues
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4.
Purification Method	Protein A purification
Research Areas	Cancer, Cell Biology, Metabolism, Signal Transduction
Clone No.	1B3
Conjugation	Unconjugated
Background	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Western Blot analysis of Hela cells using BCL2 Monoclonal Antibody at dilution of 1:1000.

IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways

IF: 8.200

Journal： Cell Communication and Signaling (2024)

DOI：10.1186/s12964-024-01921-2

Reactivity：Human
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury

IF: 7.500

Journal： BASIC RESEARCH IN CARDIOLOGY (2024)

DOI：10.1007/s00395-024-01072-y

Reactivity：Mouse

Sample Type：heart tissue
Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: in vitro insights and in silico modelling of proapoptotic gene product-compound interactions

IF: 6.100

Journal： APOPTOSIS (2024)

DOI：10.1007/s10495-024-02065-x

Reactivity：Human
A. officinarum Hance – P. cablin (Blanco) Benth drug pair improves oxidative stress, intracellular Ca2+ concentrations and apoptosis by inhibiting the AGE/RAGE axis to ameliorate diabetic gastroparesis: In vitro and in vivo studies

IF: 5.400

Journal： JOURNAL OF ETHNOPHARMACOLOGY (2024)

DOI：10.1016/j.jep.2024.117832

PMID：38280660

Reactivity：Mouse

Sample Type：gastric tissue
A potent Bioorganic azapodophyllotoxin derivative Suppresses tumor Progression in Triple negative breast Cancer: An Insight into its Inhibitory effect on tubulin polymerization and Disruptive effect on microtubule assembly

IF: 4.500

Journal： BIOORGANIC CHEMISTRY (2024)

DOI：10.1016/j.bioorg.2024.107839

Reactivity：Human
Coenzyme Q10 ameliorates cyclophosphamide-induced chemobrain by repressing neuronal apoptosis and preserving hippocampal neurogenesis: Mechanistic roles of Wnt/ β-catenin signaling pathway

IF: 3.400

Journal： NEUROTOXICOLOGY (2024)

DOI：10.1016/j.neuro.2024.08.003

Reactivity：Rat

Sample Type：hippocampal tissue
Sequence-dependent effects of hematoporphyrin derivatives (HPD) photodynamic therapy and cisplatin on lung adenocarcinoma cells

IF: 3.100

Journal： Photodiagnosis and Photodynamic Therapy (2024)

DOI：10.1016/j.pdpdt.2024.104102

Reactivity：Human
Hederagenin Induces Apoptosis of Human Hepatoma HepG2 Cells via the Mitochondrial Pathway

IF: 1.600

Journal： COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2024)

DOI：10.2174/0113862073254353230925074944

Reactivity：Human
Protective role of hesperetin in sorafenib-induced hepato- and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming

IF: 6.100

Journal： LIFE SCIENCES (2023)

DOI：10.1016/j.lfs.2023.122295

PMID：38007145

Reactivity：Mouse

Sample Type：liver tissue
Royal jelly protects brain tissue against fluoride-induced damage by activating Bcl-2/NF-κB/caspase-3/caspase-6/Bax and Erk signaling pathways in rats

IF: 5.800

Journal： ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

DOI：10.1007/s11356-023-25636-y

PMID：36759409

Reactivity：Rat

Sample Type：Brain tissue

E-AB-1001	Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1024	Goat Anti-Mouse IgG(H+L)(Biotin conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1196	HRP-Goat Anti-Mouse IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays