BCL2 Monoclonal Antibody（E-AB-22004）|-Elabscience伊莱瑞特【官网】

BCL2 Monoclonal Antibody

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货号：E-AB-22004
文献（29）
说明书

说明书

Price: ¥2310.00 ¥1420.00 ¥580.00

Size:

120 μL 60 μL 20 μL

宿主： Mouse
反应性： Human
应用性： WB

Verified Samples	Verified Samples in WB: Hela Verified Samples in IHC: Human tonsil
Dilution	WB 1:1000-2000
Clonality	Monoclonal
Isotype	IgG
Immunogen	Synthetic Peptide
Abbre	Bcl-2
Synonyms	2, AW986256, Apoptosis regulator Bcl 2, Apoptosis regulator Bcl-2, Apoptosis regulator Bcl2, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, B-cell, BCL2, Bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, Oncogene B-cell leukemia 2, PPP1R50
Swissprot	P10415
Calculated MW	26 kDa
Observed MW	26 kDa
Cellular Localization	Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Tissue Specificity	Expressed in a variety of tissues
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4.
Purification Method	Protein A purification
Research Areas	Cancer, Cell Biology, Metabolism, Signal Transduction
Clone No.	1B3
Conjugation	Unconjugated
Background	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Western Blot analysis of Hela cells using BCL2 Monoclonal Antibody at dilution of 1:1000.

Coenzyme Q10 ameliorates cyclophosphamide-induced chemobrain by repressing neuronal apoptosis and preserving hippocampal neurogenesis: Mechanistic roles of Wnt/ β-catenin signaling pathway

IF: 3.4

Journal： NEUROTOXICOLOGY (2024)

DOI：10.1016/j.neuro.2024.08.003

Reactivity：Rat

Sample Type：hippocampal tissue
Sequence-dependent effects of hematoporphyrin derivatives (HPD) photodynamic therapy and cisplatin on lung adenocarcinoma cells

IF: 3.1

Journal： Photodiagnosis and Photodynamic Therapy (2024)

DOI：10.1016/j.pdpdt.2024.104102

Reactivity：Human
Hederagenin Induces Apoptosis of Human Hepatoma HepG2 Cells via the Mitochondrial Pathway

IF: 1.6

Journal： COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2024)

DOI：10.2174/0113862073254353230925074944

Reactivity：Human
Protective role of hesperetin in sorafenib-induced hepato- and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming

IF: 6.1

Journal： LIFE SCIENCES (2023)

DOI：10.1016/j.lfs.2023.122295

PMID：38007145

Reactivity：Mouse

Sample Type：liver tissue
Royal jelly protects brain tissue against fluoride-induced damage by activating Bcl-2/NF-κB/caspase-3/caspase-6/Bax and Erk signaling pathways in rats

IF: 5.800

Journal： ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

DOI：10.1007/s11356-023-25636-y

PMID：36759409

Reactivity：Rat

Sample Type：Brain tissue
The Antioxidant and Proapoptotic Effects of Sternbergia clusiana Bulb Ethanolic Extract on Triple-Negative and Estrogen-Dependent Breast Cancer Cells In Vitro

IF: 4.500

Journal： Plants-Basel (2023)

DOI：10.3390/plants12030529

PMID：36771614

Reactivity：Human
Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms

IF: 3.9

Journal： BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

DOI：10.1007/s12011-023-03864-0

PMID：37770673

Reactivity：Rat

Sample Type：colon tissues
L-carnitine reverses methotrexate-induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC-1α/Nrf2/HO-1 axis

IF: 3.3

Journal： JOURNAL OF APPLIED TOXICOLOGY (2023)

DOI：10.1002/jat.4503

PMID：37312617

Reactivity：Rat

Sample Type：renal
Achyranthes bidentate extracts protect the IL-1β-induced osteoarthritis of SW1353 chondrocytes

IF: 2.8

Journal： JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2023)

DOI：10.1016/j.jbiosc.2023.09.008

PMID：37778956

Reactivity：Human
Infliximab Ameliorates Methotrexate-Induced Nephrotoxicity in Experimental Rat Model: Impact on Oxidative Stress, Mitochondrial Biogenesis, Apoptotic and Autophagic Machineries

IF: 2.6

Journal： CELL BIOCHEMISTRY AND BIOPHYSICS (2023)

DOI：10.1007/s12013-023-01168-7

PMID：37656380

Reactivity：Rat

Sample Type：renal tissue

E-AB-1001	Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1024	Goat Anti-Mouse IgG(H+L)(Biotin conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10 mL , 3 mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10 mL , 3 mL
E-AB-1196	HRP-Goat Anti-Mouse IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL