p70 S6 kinase alpha Monoclonal Antibody
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- 宿主： Mouse
- 反应性： Human;Mouse;Rat
- 应用性： IHC-p
| Verified Samples |
Verified Samples in IHC: Human lung carcinoma, Human breast carcinoma |
| Dilution | IHC 1:100-200 |
| Clonality | Monoclonal |
| Isotype | IgG |
| Immunogen | Recombinant Protein of P70 S6 Kinase of RPS6KB1 |
| Abbre | p70 S6 kinase alpha |
| Synonyms | 70 kDa ribosomal protein S6 kinase 1, KS6B1, P70 S6 Kinase, P70 beta 1, alpha 1, alpha 2, p70 S6 kinase, p70 S6 kinase alpha, p70 S6K, p70 S6K-alpha, p70 S6KA, p70 alpha, p70 ribosomal S6 kinase alpha, p70 ribosomal S6 kinase beta 1, p70(S6, p70(S6K) alpha |
| Swissprot | |
| Cellular Localization | Cytoplasm, Nucleus, Cytoplasm and Cell junction>synapse>synaptosome, Mitochondrion outer membrane. |
| Tissue Specificity | Widely expressed |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction |
| Clone No. | 1C7 |
| Conjugation | Unconjugated |
| Background | P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. |
| E-AB-1001 | Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1024 | Goat Anti-Mouse IgG(H+L)(Biotin conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1196 | HRP-Goat Anti-Mouse IgG(H+L) preadsorbed | 500 μL , 120 μL , 1 mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 50 mL , 18 mL , 6 mL , 3 mL |
| E-IR-R220 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50 Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50 Assays |
