TNF alpha Monoclonal Antibody
Price:
Size:
120 μL
60 μL
20 μL
- 宿主： Mouse
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC-p
| Verified Samples |
Verified Samples in WB: Recombinant protein Verified Samples in IHC: Human tonsil |
| Dilution | WB 1:1000-1:3000, IHC 1:50-1:200 |
| Clonality | Monoclonal |
| Isotype | IgG |
| Immunogen | Synthetic Peptide |
| Abbre | TNF α |
| Synonyms | APC1, APC1 protein, Cachectin, DIF, Differentiation inducing factor, Macrophage cytotoxic factor, TNF, TNF superfamily, TNF-a, TNF-alpha, TNFA, TNFSF2, Tnf, Tumor n, Tumor necrosis factor, Tumor necrosis factor alpha, macrophage derived, member 2, monocyte derived |
| Swissprot | |
| Observed MW | 17 ,25kDa |
| Cellular Localization | Secreted and Cell membrane. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Immunology, Signal Transduction |
| Clone No. | Q34 |
| Conjugation | Unconjugated |
| Background | TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
Western Blot analysis of Recombinant Human TNF a Protein using TNF alpha Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human tonsil tissue using TNF alpha Monoclonal Antibody at dilution of 1:50.
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Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model
IF: 3.200 -
Tauroursodeoxycholic Acid (TUDCA) Regulates Inflammation and Hypoxia in Autonomic Tissues of Rats with Seizures
IF: 1.600Journal： CELLULAR AND MOLECULAR BIOLOGY (2023)PMID：37130172Reactivity：RatSample Type：brain stem,heart tissue,lung tissue -
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice
IF: 14.260Journal： EMBO Molecular Medicine (2022)Reactivity：MouseSample Type：Tibialis anterior skeletal muscles ,colonic tissues -
Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway
IF: 2.873Journal： Chemical Biology & Drug Design (2022)Reactivity：RatSample Type：kidney ,liver tissues -
Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway
IF: 5.037 -
Immunoreactive definition of TNF- α, HIF-1 α, Kir6.2, Kir3.1 and M2 muscarinic receptor for cardiac and pancreatic tissues in a mouse model for type 1 diabetes
IF: 5.037Journal： LIFE SCIENCES (2021)PMID：34389402Reactivity：MouseSample Type：pancreas tissue, heart tissue -
Synergistic neuroprotective effects of hyperbaric oxygen and methylprednisolone following contusive spinal cord injury in rat
IF: 1.985Journal： JOURNAL OF SPINAL CORD MEDICINE (2021)Reactivity：RatSample Type：spinal cord tissue
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