Active CASP3 Monoclonal Antibody-Elabscience伊莱瑞特【官网】

Active CASP3 Monoclonal Antibody

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货号：E-AB-22115
文献（19）
说明书

说明书

Price: ¥2310.00 ¥1420.00 ¥580.00

Size:

120 μL 60 μL 20 μL

宿主： Mouse
反应性： Human;Mouse;Rat
应用性： WB;IHC-p;IF

Verified Samples	Verified Samples in WB: Hela, 3T3, Rat brain Verified Samples in IHC: Human liver
Dilution	WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200
Clonality	Monoclonal
Isotype	IgG
Immunogen	Recombinant Protein
Abbre	Active Caspase-3
Synonyms	A830040C14Rik, Apopain, CASP-3, CASP3, CC3, CPP-32, CPP32, CPP32B, Casp3a, Caspase 3, Caspase-3 subunit p12, Cysteine p, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, apoptosis-related cysteine protease a
Swissprot	P42574
Observed MW	17 kDa
Cellular Localization	Cytoplasm.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4.
Purification Method	Protein A purification
Research Areas	Cancer, Cell Biology, Metabolism, Neuroscience
Clone No.	5A2
Conjugation	Unconjugated
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain with Active CASP3 Monoclonal Antibody

Immunohistochemistry of paraffin-embedded Human liver tissue using Active CASP3 Monoclonal Antibody at dilution of 1:200.

Evidence that tirzepatide protects against diabetes-related cardiac damages

IF: 9.300

Journal： Cardiovascular Diabetology (2024)

DOI：10.1186/s12933-024-02203-4

PMID：38555463

Reactivity：Human
Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study

IF: 4.100

Journal： JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2024)

DOI：10.1016/j.jsbmb.2024.106463

PMID：38246202

Reactivity：Mouse

Sample Type：infantile ovary
Apelin receptor modulation mitigates letrozole-induced polycystic ovarian pathogenesis in mice

IF: 3.700

Journal： CYTOKINE (2024)

DOI：10.1016/j.cyto.2024.156639

Reactivity：Mouse

Sample Type：ovary tissue
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model

IF: 3.500

Journal： PSYCHOPHARMACOLOGY (2024)

DOI：10.1007/s00213-024-06622-9

Reactivity：Mouse

Sample Type：cerebral cortex tissue
Effects of dopaminergic neuron degeneration on osteocyte apoptosis and osteogenic markers in 6-OHDA male rat model of Parkinson's disease

IF: 3.500

Journal： BONE (2024)

DOI：10.1016/j.bone.2024.117271

Reactivity：Rat

Sample Type：bone tissue
Expression and localization of apelin and apelin receptor protein in the oviduct of letrozole-induced hyperandrogenized mice

IF: 3.300

Journal： CELL BIOLOGY INTERNATIONAL (2024)

DOI：10.1002/cbin.12164

Reactivity：Mouse

Sample Type：oviduct
Comparative expression and localization of visfatin, chemerin, and chemerin receptor proteins in a heat-stressed mouse testis

IF: 2.700

Journal： TISSUE & CELL (2024)

DOI：10.1016/j.tice.2024.102374

Reactivity：Mouse

Sample Type：testis
Hederagenin Induces Apoptosis of Human Hepatoma HepG2 Cells via the Mitochondrial Pathway

IF: 1.600

Journal： COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2024)

DOI：10.2174/0113862073254353230925074944

Reactivity：Human
Phytosphingosine inhibits the growth of lung adenocarcinoma cells by inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo

IF: 5.100

Journal： CHEMICO-BIOLOGICAL INTERACTIONS (2023)

DOI：10.1016/j.cbi.2023.110795

PMID：37956922

Reactivity：Human
Cycas pectinata stimulates germ cell proliferation in mouse testes

IF: 4.400

Journal： PROCESS BIOCHEMISTRY (2023)

DOI：10.1016/j.procbio.2023.05.026

Reactivity：Mouse

Sample Type：testis

E-AB-1001	Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1011	Goat Anti-Mouse IgG(H+L)(Cyanine3 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1015	Goat Anti-Mouse IgG(H+L)(FITC conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1024	Goat Anti-Mouse IgG(H+L)(Biotin conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1059	Goat Anti-Mouse IgG(H+L)(Elab Fluor® 594 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1076	Goat Anti-Mouse IgG(H+L)(Elab Fluor® 647 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1196	HRP-Goat Anti-Mouse IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays