AMACR Monoclonal Antibody

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- 宿主: Mouse
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC-p;IF
Verified Samples |
Verified Samples in WB: HepG2, Mouse kidney Verified Samples in IHC: Human stomach Verified Samples in IF: Mouse kidney |
Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300 |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | Synthetic Peptide |
Abbre | AMACR |
Synonyms | 2 methylacyl CoA racemase, 2-methylacyl-CoA racemase, AMACR, AMACRD, Alpha methylacyl CoA racemase, Alpha-methylacyl-CoA racemase, Amacr, CBAS4, EC 5.1.99.4, Macr1, RACE, RM |
Swissprot | |
Calculated MW | 42 kDa |
Observed MW | 42 kDa |
Cellular Localization | Peroxisome. Mitochondrion. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
Purification Method | Protein A purification |
Research Areas | Cell Biology, Metabolism, Signal Transduction |
Clone No. | 1F1 |
Conjugation | Unconjugated |
Background | This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. |