ATG7 Monoclonal Antibody

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- 宿主: Mouse
- 反应性: Human;Mouse;Rat
- 应用性: IHC-p;IF
Verified Samples |
Verified Samples in IHC: Human uterus Verified Samples in IF: Mouse spleen |
Dilution | IHC 1:50-300, IF 1:50-1:200 |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | Recombinant Protein of ATG7 |
Abbre | ATG7 |
Synonyms | 1810013K23Rik, APG7, APG7 autophagy 7 like, APG7 autophagy 7-like (S. cerevisiae), APG7 like, APG7-like, APG7L, ATG 7, ATG12-activating enzyme E1 ATG7, ATG7, ATG7 autophagy related 7 ho, ATG7 autophagy related 7 homolog (S. cerevisiae), Apg 7, S. cerevisiae, homolog of |
Swissprot | |
Cellular Localization | Cytoplasm. Preautophagosomal structure. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. |
Tissue Specificity | Widely expressed, Especially in kidney, Liver, Lymph nodes and bone marrow |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
Purification Method | Protein A purification |
Research Areas | Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction |
Clone No. | 1A1 |
Conjugation | Unconjugated |
Background | ATG7 (Autophagy Related 7) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and ubiquitin activating enzyme activity. This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. |