CD284 Polyclonal Antibody
Price:
Size:
200 μL
120 μL
60 μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB: Jurkat, RAW264.7, A20, Mouse spleen, Mouse lung, Mouse thymus, Rat spleen, Rat lung, Rat thymus Verified Samples in IHC: Mouse spleen, Rat lymph |
| Dilution | WB 1:500-1:2000, IHC 1:500-1:2000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse TLR4. |
| Abbre | CD284 |
| Synonyms | ARMD10, CD284, CD284 antigen, Homolog of Drosophila toll, TLR 4, TLR4, TOLL, Toll like receptor 4, Toll-like receptor 4, hToll |
| Swissprot | |
| Calculated MW | 95 kDa |
| Observed MW | 95 kDa |
| Cellular Localization | Membrane. |
| Concentration | 0.9 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Immunology, Microbiology |
| Conjugation | Unconjugated |
| Background | TLR4,also named as CD284,belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88,TIRAP and TRAF6,leading to NF-kappa-B activation,cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described. |
Western Blot analysis of various samples using CD284 Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD284 Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded rat lymph using CD284 Polyclonal Antibody at dilution of 1:1000.
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HMGN1 down-regulation in the diabetic kidney attenuates tubular cells injury and protects against renal inflammation via suppressing MCP-1 and KIM-1 expression through TLR4
IF: 5.400Journal： JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2024)PMID：38409569Reactivity：Mouse,HumanSample Type：diabetic kidney tissue -
A Novel Synbiotic Protects Against DSS-Induced Colitis in Mice via Anti-inflammatory and Microbiota-Balancing Properties
IF: 4.400Journal： Probiotics and Antimicrobial Proteins (2024)Reactivity：MouseSample Type：Colon tissue -
Phosphocreatine ameliorates hepatocellular apoptosis mediated by protecting mitochondrial damage in liver ischemia/reperfusion injury through inhibiting TLR4 and Agonizing Akt Pathway
IF: 2.700Journal： TISSUE & CELL (2024)Reactivity：Mouse,HumanSample Type：liver tissue -
Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor- and non-motor features of Parkinson disease in mice: Insight into mechanisms of neuroprotection
IF: 5.400Journal： JOURNAL OF ETHNOPHARMACOLOGY (2023)PMID：38128890Reactivity：MouseSample Type：brain tissue -
Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF-κB/TNF-α signaling pathways: Experimental study
IF: 3.600Journal： CELL BIOCHEMISTRY AND FUNCTION (2023)DOI：10.1002/cbf.3790PMID：36970761Reactivity：RatSample Type：kidney,liver -
Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway
IF: 5.037 -
Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines
IF: 4.799Journal： INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)PMID：33783487Reactivity：MouseSample Type：Tissue homogenate(corneas) -
Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-κB signalling cascades in Wistar Rats
IF: 3.765 -
Effect of Bufei Yishen Granules Combined with Electroacupuncture in Rats with Chronic Obstructive Pulmonary Disease via the Regulation of TLR-4/NF-κB Signaling
IF: 1.984Journal： Evidence-based Complementary and Alternative Medicine (2019)PMID：31275415Reactivity：RatSample Type：lung tissues
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