CD4 Monoclonal Antibody-Elabscience伊莱瑞特【官网】

CD4 Monoclonal Antibody

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货号：E-AB-22098
文献（5）
说明书

说明书

Price: ¥2310.00 ¥1420.00 ¥580.00

Size:

120 μL 60 μL 20 μL

宿主： Mouse
反应性： Human;Mouse;Rat
应用性： IHC-p;IF

Verified Samples	Verified Samples in IHC: Human stomach, Mouse brain Verified Samples in IF: Mouse colonic
Dilution	IHC 1:100-1:300, IF 1:50-200
Clonality	Monoclonal
Isotype	IgG
Immunogen	Synthetic Peptide
Abbre	CD4
Synonyms	CD 4, CD4, CD4 (L3T4), CD4 antigen, CD4 antigen (p55), CD4 molecule, CD4 receptor, CD4+ Lymphocyte deficiency, CD4mut, L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, MGC165891, OTTHUMP00000238897, T cell antigen T4, T cell antigen T4/LEU3, T cell differentiati, included, p55
Swissprot	P01730
Cellular Localization	Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Tissue Specificity	Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4.
Purification Method	Protein A purification
Research Areas	Cancer, Immunology, Stem Cells
Clone No.	9G1
Conjugation	Unconjugated
Background	This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Immunohistochemistry of paraffin-embedded Human stomach tissue using CD4 Monoclonal Antibody at dilution of 1:200.

Immunohistochemistry of paraffin-embedded Mouse brain tissue using CD4 Monoclonal Antibody at dilution of 1:200.

Immunofluorescence analysis of Mouse colonic tissue with CD4 Monoclonal Antibody.

Dual-Targeted Self-Adjuvant Heterocyclic Lipidoid@Polyester Hybrid Nanovaccines for Boosting Cancer Immunotherapy

IF: 15.800

Journal： ACS Nano (2024)

DOI：10.1021/acsnano.4c00392

Reactivity：mouse
Unraveling CCL20's role by regulating Th17 cell chemotaxis in experimental autoimmune prostatitis

IF: 4.300

Journal： JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2024)

DOI：10.1111/jcmm.18445
Immunomodulatory effects of chronic trichinellosis on Toxoplasma gondii RH virulent strain in experimental rats

IF: 3.400

Journal： Pathogens and Global Health (2023)

DOI：10.1080/20477724.2023.2191233

PMID：36922743PMC10177679

Reactivity：Rat

Sample Type：brain tissues
Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation

IF: 6.304

Journal： Cell Death & Disease (2020)

DOI：10.1038/s41419-020-02891-2

PMID：32829384

Reactivity：Mouse

Sample Type：retina
Sexual dimorphism in Th17/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis

IF: 6.306

Journal： BRAIN BEHAVIOR AND IMMUNITY (2018)

DOI：10.1016/j.bbi.2018.11.311

PMID：30476564

Reactivity：Rat

Sample Type：Cell

E-AB-1001	Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1011	Goat Anti-Mouse IgG(H+L)(Cyanine3 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1015	Goat Anti-Mouse IgG(H+L)(FITC conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1024	Goat Anti-Mouse IgG(H+L)(Biotin conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1059	Goat Anti-Mouse IgG(H+L)(Elab Fluor® 594 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1076	Goat Anti-Mouse IgG(H+L)(Elab Fluor® 647 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1196	HRP-Goat Anti-Mouse IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays

技术资源

• 如何明智选择抗体？

• 二抗选择指南

• Western Blot内参抗体选择原则

• 免疫组化抗体选择要点

• Western实验步骤

• Western Blot常见问题分析

• 不同浓缩胶体积所对应的各种组分的取样量

• 石蜡切片免疫组化实验步骤

• 免疫荧光实验指南

• 免疫共沉淀实验指南

全部分类

CD4 Monoclonal Antibody

Dual-Targeted Self-Adjuvant Heterocyclic Lipidoid@Polyester Hybrid Nanovaccines for Boosting Cancer Immunotherapy

Unraveling CCL20's role by regulating Th17 cell chemotaxis in experimental autoimmune prostatitis

Immunomodulatory effects of chronic trichinellosis on Toxoplasma gondii RH virulent strain in experimental rats

Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation

Sexual dimorphism in Th17/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis

实验操作视频

技术资源