(KO Validated) BAX Polyclonal Antibody
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Price:
Size:
200 μL
120 μL
60 μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB: 293T, 293T, HeLa, Raji, RAW264.7, Mouse lung Verified Samples in IHC: Rat ovary, Human lung cancer, Human breast cancer, Human stomach, Mouse liver, Mouse kidney |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:200 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic peptide of human BAX (NP_620116.1). |
| Abbre | BAX |
| Synonyms | BAX, BCL2L4 |
| Swissprot | |
| Calculated MW | 4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa |
| Observed MW | 20 kDa |
| Cellular Localization | Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Metabolism |
| Conjugation | Unconjugated |
| Background | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. |
Western blot analysis of extracts of various cell lines using BAX Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts from normal (control) and BAX knockout (KO) 293T cells using BAX Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Rat ovary using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human lung cancer using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human breast cancer using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human stomach using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse kidney using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).
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Nanoplastics induced health risk: Insights into intestinal barrier homeostasis and potential remediation strategy by dietary intervention
IF: 12.200Journal： JOURNAL OF HAZARDOUS MATERIALS (2024)Reactivity：MouseSample Type：intestine tissue -
Potential anti-liver cancer targets and mechanisms of kaempferitrin based on network pharmacology, molecular docking and experimental verification
IF: 7.000Journal： COMPUTERS IN BIOLOGY AND MEDICINE (2024)Reactivity：Mouse,HumanSample Type：SMMC-7721 cell-Xenograft -
Phosphocreatine attenuates doxorubicin-induced nephrotoxicity through inhibition of apoptosis, and restore mitochondrial function via activation of Nrf2 and PGC-1α pathways
IF: 4.700Journal： CHEMICO-BIOLOGICAL INTERACTIONS (2024)Reactivity：RatSample Type：kidney tissue -
A potent Bioorganic azapodophyllotoxin derivative Suppresses tumor Progression in Triple negative breast Cancer: An Insight into its Inhibitory effect on tubulin polymerization and Disruptive effect on microtubule assembly
IF: 4.500 -
Sequence-dependent effects of hematoporphyrin derivatives (HPD) photodynamic therapy and cisplatin on lung adenocarcinoma cells
IF: 3.100Journal： Photodiagnosis and Photodynamic Therapy (2024)Reactivity：Human -
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
IF: 2.900Journal： JOURNAL OF MOLECULAR HISTOLOGY (2024)Reactivity：RatSample Type：colon tissue -
Phosphocreatine ameliorates hepatocellular apoptosis mediated by protecting mitochondrial damage in liver ischemia/reperfusion injury through inhibiting TLR4 and Agonizing Akt Pathway
IF: 2.700Journal： TISSUE & CELL (2024)Reactivity：Mouse,HumanSample Type：liver tissue -
Caffeic acid phenethyl ester ameliorates imidacloprid-induced acute toxicity in the rat cerebral cortex
IF: 5.785Journal： ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2022)PMID：36191819Reactivity：RatSample Type：brain tissue -
Royal jelly regulates the caspase, Bax and COX-2, TNF-α protein pathways in the fluoride exposed lung damage in rats
IF: 2.586 -
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