(KO Validated) BAX Polyclonal Antibody（E-AB-63606）|-Elabscience伊莱瑞特【官网】

(KO Validated) BAX Polyclonal Antibody

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货号：E-AB-63606
文献（17）
说明书

说明书

Price: ¥4020.00 ¥2520.00 ¥1580.00

Size:

200 μL 120 μL 60 μL

宿主： Rabbit
反应性： Human;Mouse;Rat
应用性： WB;IHC

Verified Samples	Verified Samples in WB: 293T, 293T, HeLa, Raji, RAW264.7, Mouse lung Verified Samples in IHC: Rat ovary, Human lung cancer, Human breast cancer, Human stomach, Mouse liver, Mouse kidney
Dilution	WB 1:500-1:2000, IHC 1:100-1:200
Clonality	Polyclonal
Isotype	IgG
Immunogen	A synthetic peptide of human BAX (NP_620116.1).
Abbre	BAX
Synonyms	BAX, BCL2L4
Swissprot	Q07812
Calculated MW	4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa
Observed MW	20 kDa
Cellular Localization	Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purification Method	Affinity purification
Research Areas	Cancer, Cell Biology, Metabolism
Conjugation	Unconjugated
Background	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Western blot analysis of extracts of various cell lines using BAX Polyclonal Antibody at dilution of 1:1000.

Western blot analysis of extracts from normal (control) and BAX knockout (KO) 293T cells using BAX Polyclonal Antibody at dilution of 1:1000.

Immunohistochemistry of paraffin-embedded Rat ovary using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded Human lung cancer using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded Human breast cancer using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded Human stomach using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded Mouse kidney using BAX Polyclonal Antibody at dilution of 1:100 (40x lens).

Caffeic acid phenethyl ester ameliorates imidacloprid-induced acute toxicity in the rat cerebral cortex

IF: 5.785

Journal： ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2022)

DOI：10.1016/j.etap.2022.103980

PMID：36191819

Reactivity：Rat

Sample Type：brain tissue
Royal jelly regulates the caspase, Bax and COX-2, TNF-α protein pathways in the fluoride exposed lung damage in rats

IF: 2.586

Journal： TISSUE & CELL (2022)

DOI：10.1016/j.tice.2022.101754

Reactivity：Rat

Sample Type：lung tissue
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model

IF: 2.245

Journal： CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2022)

DOI：10.1139/cjpp-2022-0176

Reactivity：Rat

Sample Type：cardiac tissue,renal tissue
Cysteamine Attenuate Intestinal Reperfusion Injury Induced by Occlusion of Mesenteric Artery by Enhancing Intracellular Thiol Activities

Journal： Drug Research (2022)

DOI：10.1055/a-1974-9132

Reactivity：Rat

Sample Type：Intestinal
Lysophosphatidic Acid Alters The Expression of Apoptosis Related Genes and miR-22 in Cultured and Autotransplanted Ovaries

IF: 2.479

Journal： Cell Journal (2021)

DOI：10.22074/cellj.2021.7303

Reactivity：Mouse

Sample Type：ovarian tissue
Follicular development and the expression of BAX and vascular endothelial growth factor in transplanted ovaries in uni- and bilateral ovariectomized mice: An experimental study

Journal： International Journal of Reproductive Biomedicine (2021)

DOI：10.18502/ijrm.v19i4.9062

PMID：33997595

Reactivity：Mouse

Sample Type：ovaries
Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line

Journal： International Journal of Molecular and Cellular Medicine (2021)

DOI：10.22088/IJMCM.BUMS.10.1.11

Reactivity：Human

E-AB-1003	Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10 mL , 3 mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10 mL , 3 mL
E-AB-1194	HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL