N-cadherin Polyclonal Antibody-Elabscience伊莱瑞特【官网】

N-cadherin Polyclonal Antibody

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货号：E-AB-70061
文献（17）
说明书

说明书

Price: ¥3300.00 ¥2220.00 ¥1380.00

Size:

200 μL 120 μL 60 μL

宿主： Rabbit
反应性： Human;Mouse;Rat
应用性： WB;IHC

Verified Samples	Verified Samples in WB: HCT116, HUVEC, Hela, Rat liver, Rat kidney, Rat brain, Mouse liver, Mouse kidney, Mouse brain Verified Samples in IHC: Human liver, Mouse liver, Rat liver
Dilution	WB 1:500-1:2000, IHC 1:300-1:800
Clonality	Polyclonal
Isotype	IgG
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse N-cadherin
Abbre	N-cadherin
Synonyms	CADH2, CD325, CD325 antigen, CDH2, CDHN, CDw325, CDw325 an, Cadherin 2, Cadherin 2 N cadherin neuronal, Cadherin 2 type 1, Cadherin 2 type 1 N cadherin neuronal, Cadherin-2, Cadherin2, Calcium dependent adhesion protein neuronal, N-cadherin (neuronal), type 1
Swissprot	P19022, P15116, Q9Z1Y3
Calculated MW	100/120 /140 kDa
Observed MW	120 kDa
Cellular Localization	Cell junction, Cell membrane, Membrane.
Concentration	200 μg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.
Purification Method	Affinity purification
Research Areas	Cancer, Signal Transduction, Stem Cells
Conjugation	Unconjugated
Background	Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin),also known as CDH2 (cadherin 2),is a classical member of the cadherin superfamily which also include E-,P-,R-,and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons,endothelial cells and cardiac myocytes . N-cadherin has functions in early brain morphogenesis,synaptogenesis and synaptic plasticity .

Western Blot analysis of various samples using N-cadherin Polyclonal Antibody at dilution of 1:1000.

Immunohistochemistry analysis of paraffin-embedded human liver using N-cadherin Polyclonal Antibody at dilution of 1:500.

Immunohistochemistry analysis of paraffin-embedded Mouse liver using N-cadherin Polyclonal Antibody at dilution of 1:500.

Immunohistochemistry analysis of paraffin-embedded rat liver using N-cadherin Polyclonal Antibody at dilution of 1:500.

LDH-A Inhibitor as a Remedy to Potentiate the Anticancer Effect of Docetaxel in Prostate Cancer

IF: 3.900

Journal： Journal of Cancer (2024)

DOI：10.7150/jca.86283

PMID：38213726

Reactivity：Mouse

Sample Type：Tramp-C2 cell-xenograft
Caspase-9 suppresses metastatic behavior of MDA-MB-231 cells in an adaptive organoid model

IF: 3.800

Journal： Scientific Reports (2024)

DOI：10.1038/s41598-024-65711-z

Reactivity：Human
Nimbolide attenuates hepatocellular carcinoma by regulating miRNAs 21, 145 and 221 and their target gene expression

IF: 2.600

Journal： GENE (2024)

DOI：10.1016/j.gene.2024.149126

Reactivity：Mouse

Sample Type：liver tissue
Multimodal tumor suppression by METTL3 gene knockdown in melanoma and colon cancer cells

IF: 2.100

Journal： HISTOCHEMISTRY AND CELL BIOLOGY (2024)

DOI：10.1007/s00418-024-02346-1

Reactivity：Human
Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells

IF: 7.900

Journal： PHYTOMEDICINE (2023)

DOI：10.1016/j.phymed.2023.154914

PMID：37321076

Reactivity：Human
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

IF: 7.500

Journal： Cell and Bioscience (2023)

DOI：10.1186/s13578-023-00963-2

PMID：36683064

Reactivity：Human
Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer stem cells

IF: 5.800

Journal： EXPERT OPINION ON THERAPEUTIC TARGETS (2023)

DOI：10.1080/14728222.2023.2266572

PMID：37787493

Reactivity：Human

Sample Type：colon, colonosphere
Palmitic Acid Inhibits the Growth and Metastasis of Gastric Cancer by Blocking the STAT3 Signaling Pathway

IF: 5.200

Journal： Cancers (2023)

DOI：10.3390/cancers15020388

PMID：36672337

Reactivity：Human
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells

IF: 4.100

Journal： Journal of Cell Communication and Signaling (2023)

DOI：10.1007/s12079-023-00756-9

PMID：37162635

Reactivity：Human
Conjugation of VEGFR1/R2-targeting peptide with gold nanoparticles to enhance antiangiogenic and antitumoral activity

IF: 9.429

Journal： JOURNAL OF NANOBIOTECHNOLOGY (2022)

DOI：10.1186/s12951-021-01198-4

PMID：34983556

Sample Type：mammary carcinoma tumors (4T1 tumors)

E-AB-1003	Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1194	HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays