SARS-CoV-2 NSP3 Polyclonal Antibody(2019-nCoV)
Price:
Size:
100 μL
50 μL
- 宿主： Rabbit
- 反应性： SARS-COV2
- 应用性： ELISA
| Dilution | ELISA 1:4000-1:8000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant SARS-CoV-2 NSP3 |
| Synonyms | Non-structural protein 3, PL-PRO, PL2-PRO, Papain-like proteinase, Replicase polyprotein 1a |
| Concentration | 0.33mg/ml |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS, pH 7.4, containing 0.05% proclin 300, 50% glycerol. |
| Conjugation | Unconjugated |
| Background | Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling. |
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