SIRT1 Polyclonal Antibody
Price:
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC: Human tonsil, Mouse testis, Rat testis |
| Dilution | IHC 1:200-1:800 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse SIRT1 |
| Abbre | SIRT1 |
| Synonyms | 75SirT1, HST2, NAD dependent deacetylase sirtuin 1, NAD dependent protein deacetylase sirtuin 1, OTTHUMP00000198111, OTTHUMP00000198112, Regulatory protein SIR2 homolog 1, S. cerevisiae, S.cer, SIR1, SIR2, SIR2 like 1, SIR2 like protein 1, hSIR2, hSIRT1, homolog of |
| Swissprot | |
| Cellular Localization | Cytoplasm. Mitochondrion and Nucleus, PML body. Cytoplasm. Nucleus. Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). |
| Concentration | 0.57 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Background | SIRT1,also named as SIR2L1,contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection,including: activation of endothelial nitric oxide synthase,insulin receptor signalling,and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO,Hif-2a,and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53,specifically at Lysine 382. |
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Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain.
IF: 3.700Journal： Pain Physician (2023)DOI：PMID:37192244PMID：37192244Reactivity：RatSample Type：dorsal root ganglion (DRG) -
L-carnitine reverses methotrexate-induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC-1α/Nrf2/HO-1 axis
IF: 3.300Journal： JOURNAL OF APPLIED TOXICOLOGY (2023)DOI：10.1002/jat.4503PMID：37312617Reactivity：RatSample Type：kidney -
SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5
IF: 3.811Journal： CELLULAR AND MOLECULAR NEUROBIOLOGY (2019)PMID：31270711Reactivity：MouseSample Type：spinal cord
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| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500 μL , 120 μL , 1 mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 50 mL , 18 mL , 6 mL , 3 mL |
| E-IR-R220 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50 Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50 Assays |
