TNF Polyclonal Antibody-Elabscience伊莱瑞特【官网】

TNF Polyclonal Antibody

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货号：E-AB-52065
文献（7）
说明书

说明书

Price: ¥2365.00 ¥1640.00 ¥1010.00 ¥420.00

Size:

200 μL 120 μL 60 μL 20 μL

宿主： Rabbit
反应性： Human;Mouse;Rat
应用性： IHC

Verified Samples	Verified Samples in IHC: Human liver cancer, Human cervical cancer
Dilution	IHC 1:30-1:150
Clonality	Polyclonal
Isotype	IgG
Immunogen	Synthetic peptide of human TNF
Abbre	TNF
Synonyms	APC1, APC1 protein, Cachectin, DIF, Differentiation inducing factor, Macrophage cytotoxic factor, TNF, TNF superfamily, TNF-a, TNF-alpha, TNFA, TNFSF2, Tnf, Tumor n, Tumor necrosis factor, Tumor necrosis factor alpha, macrophage derived, member 2, monocyte derived
Swissprot	P01375
Cellular Localization	Secreted and Cell membrane.
Concentration	1.14 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.05% NaN3 and 40% Glycerol, pH 7.4.
Purification Method	Antigen affinity purification
Research Areas	Cancer, Cardiovascular, Metabolism, Immunology, Signal Transduction
Conjugation	Unconjugated
Background	TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TNF Polyclonal Antibody at dilution of 1:40(×200)

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TNF Polyclonal Antibody at dilution of 1:40(×200)

Therapeutic Potential of the Linalool against Cadmium-Induced Testicular Tissue Damage

IF: 3.600

Journal： JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

DOI：10.1016/j.jtemb.2024.127455

Reactivity：Rat

Sample Type：testicular tissue
Kaempferol sophoroside glucoside mitigates acetaminophen-induced hepatotoxicity: Role of Nrf2/NF-κB and JNK/ASK-1 signaling pathways

IF: 3.400

Journal： Heliyon (2024)

DOI：10.1016/j.heliyon.2024.e31448

Reactivity：Mouse

Sample Type：liver
The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-?nduced Testicular Tissue Damage

IF: 2.600

Journal： Reproductive Sciences (2024)

DOI：10.1007/s43032-024-01567-y

Reactivity：Rat

Sample Type：testicular tissue
The rejuvenating influence of young plasma on aged intestine

IF: 5.300

Journal： JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2023)

DOI：10.1111/jcmm.17926

PMID：37610839

Reactivity：Rat

Sample Type：ileum,colon
N-Acetylcysteine May Regulate Altered Meteorin-Like Levels in Testicular Tissue due to Aluminum Exposure

IF: 3.900

Journal： BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

DOI：10.1007/s12011-023-03656-6

PMID：37016183

Reactivity：Rat

Sample Type：testicular tissue
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics

IF: 3.800

Journal： CELL STRESS & CHAPERONES (2023)

DOI：10.1007/s12192-023-01373-6

PMID：37644219PMC10746646

Reactivity：Rat

Sample Type：heart tissue
Synergistic neuroprotective effects of hyperbaric oxygen and methylprednisolone following contusive spinal cord injury in rat

IF: 1.985

Journal： JOURNAL OF SPINAL CORD MEDICINE (2021)

DOI：10.1080/10790268.2021.1896275

Reactivity：Rat

Sample Type：spinal cord tissue

E-AB-1003	Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1194	HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays