XRCC4 Monoclonal Antibody

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- 宿主: Mouse
- 反应性: Human
- 应用性: WB;IHC-p;IF;IP
Verified Samples |
Verified Samples in WB: Hela, 293T Verified Samples in IHC: Human breast cancer Verified Samples in IF: Human liver cancer |
Dilution | WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300 |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | Synthetic Peptide |
Abbre | XRCC4 |
Synonyms | DNA double strand break repair and V(D)J recombination protein XRCC4, DNA repair protein XRCC4, SSMED, X ray repair complementing defective repair in Chinese hamster cells 4, X ray repair cross complementing 4, X ray repair cross complementing protein 4, X-ray |
Swissprot | |
Calculated MW | 38 kDa |
Observed MW | 38 kDa |
Cellular Localization | Nucleus. |
Tissue Specificity | Widely expressed |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
Purification Method | Protein A purification |
Research Areas | Cancer, Epigenetics and Nuclear Signaling |
Clone No. | 8K2 |
Conjugation | Unconjugated |
Background | Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. |