YBX1 Polyclonal Antibody
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- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC: Human cervical cancer, Human ovarian cancer |
| Dilution | IHC 1:30-1:150 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide of human YBX1 |
| Abbre | YBX1 |
| Synonyms | BP 8, CBF-A, CCAAT binding transcription factor I subunit A, CCAAT-binding transcription factor I subunit A, CSDA2, CSDB, DBPB, DNA binding protein B, DNA-binding protein B, EFI-A, Enhancer factor I subunit A, MDR NF1, MGC104858, MGC110976, MGC117250, NSEP 1, NSEP1, Nucle |
| Swissprot | |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress. |
| Concentration | 0.6 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol, pH 7.4. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Background | This protein mediates pre-mRNA alternative splicing regulation. It binds to splice sites in pre-mRNA and regulates splice site selection and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It can regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). |
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500 μL , 120 μL , 1 mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 50 mL , 18 mL , 6 mL , 3 mL |
| E-IR-R220 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50 Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50 Assays |
