Cortisol Binding Globulin/CBG/SERPINA6 Polyclonal Antibody(Capture/Detector)
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- 宿主： Rabbit
- 反应性： Human;Mouse
- 应用性： WB;IF;ELISA Capture/Detector
| Verified Samples |
Verified Samples in WB: Human plasma Verified Samples in IF: NIH-3T3 Verified Samples in ELISA: Recombinant Human Cortisol Binding Globulin/CBG/SERPINA6 protein, Human serum, Human plasma |
| Dilution | WB 1:500-1:1000, IF 1:50-1:200, ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Recombinant Human Cortisol Binding Globulin/CBG/SERPINA6 SERPINA6 Protein expressed by Mammalian |
| Abbre | Cortisol Binding Globulin/CBG/SERPINA6 |
| Synonyms | Corticosteroid-binding gLobuLin, CBG, Serpin A6, Transcortin, SERPINA6, CBG |
| Swissprot | |
| Calculated MW | 45 kDa |
| Observed MW | 60 kDa |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Signal Transduction, Metabolism |
| Conjugation | Unconjugated |
| Background | Corticosteroid-binding globulin (CBG),also known as SerpinA6,is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG,and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context,CBG directs glucocorticoids to sites of inflammation,and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration,and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable,human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels. |
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