BECN1 Polyclonal Antibody-Elabscience伊莱瑞特【官网】

BECN1 Polyclonal Antibody

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货号：E-AB-70093
说明书

说明书

Price: ¥3300.00 ¥2220.00 ¥1380.00

Size:

200 μL 120 μL 60 μL

宿主： Rabbit
反应性： Human;Mouse
应用性： IHC;IF

Verified Samples	Verified Samples in IHC: Human tonsil Verified Samples in IF: Mouse kidney
Dilution	IHC 1:300-1:1000, IF 1:100-1:500
Clonality	Polyclonal
Isotype	IgG
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Beclin1
Abbre	BECN1
Synonyms	APG6, ATG 6, ATG6, ATG6 autophagy related 6 homolog, BECN 1, BECN1, Bcl-2-interacting protein beclin, Beclin 1 (coiled coil moesin like BCL2 interacting protein), Beclin 1 autophagy related, Beclin-1, Beclin1, Becn1, C, Coiled coil myosin like BCL2 interacting protein
Swissprot	Q14457, O88597, Q91XJ1
Cellular Localization	Golgi apparatus>trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.
Concentration	2.6 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.
Purification Method	Affinity purification
Research Areas	Cancer, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Signal Transduction
Conjugation	Unconjugated
Background	Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

Immunohistochemistry analysis of paraffin-embedded human tonsil using BECN1 Polyclonal Antibody at dilution of 1:500.

Immunofluorescence analysis of paraffin-embedded mouse kidney using BECN1 Polyclonal Antibody at dilution of 1:300.

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E-AB-1010	Goat Anti-Rabbit IgG(H+L)(Cyanine3 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1014	Goat Anti-Rabbit IgG(H+L)(FITC conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1060	Goat Anti-Rabbit IgG(H+L)(Elab Fluor® 594 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1075	Goat Anti-Rabbit IgG(H+L)(Elab Fluor® 647 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1099	Elab Fluor® Violet 450-Goat Anti-Rabbit IgG(H+L)	500 μL , 120 μL , 1 mL
E-AB-1194	HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays