Caspase-3 Polyclonal Antibody
Price:
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IF
| Verified Samples |
Verified Samples in WB: Jurkat, Jurkat, HeLa, 293T, NIH/3T3, Mouse lung Verified Samples in IF: HeLa |
| Dilution | WB 1:500-1:2000, IF 1:50-1:200 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic peptide of human Caspase-3 (NP_004337.2). |
| Abbre | Caspase-3 |
| Synonyms | Active Caspase 3, CASP3, CPP32, CPP32B, Caspase 3, Caspase-3 p12, SCA-1, active Caspase-3, caspase-3 |
| Swissprot | |
| Calculated MW | 31 kDa |
| Observed MW | 15 kDa/35 kDa |
| Cellular Localization | Cytoplasm. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Neuroscience |
| Conjugation | Unconjugated |
| Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
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Semaphorin 3A attenuates the hypoxia suppression of osteogenesis in periodontal ligament stem cells
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Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling
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Nigral and ventral tegmental area lesioning induces testicular and sperm morphological abnormalities in a rotenone model of Parkinson’s disease
IF: 3.292Journal： ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020)PMID：32439558Reactivity：RatSample Type：Tissue -
Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice
IF: 2.971 -
Osteopontin Promotes Bone Destruction in Periapical Periodontitis by Activating the NF-κB Pathway
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Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway
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