Cleaved-CASP3 p17 (D175) Polyclonal Antibody
Price:
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB: Hela, Mouse samples, Rat heart, Recombinant protein, Rat lung, Rat lung, Rat brain, Mouse colon, Mouse kidney Verified Samples in IHC: Human stomach cancer Verified Samples in IF: Rat liver |
| Dilution | WB 1:500-2000, IHC 1:50-300, IF 1:50-300 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the Internal region of human Caspase-3 p17 |
| Abbre | Cleaved-Caspase-3 p17 (D175) |
| Synonyms | A830040C14Rik, Apopain, CASP-3, CASP3, CC3, CPP-32, CPP32, CPP32B, Casp3a, Caspase 3, Caspase-3 subunit p12, Cysteine p, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, apoptosis-related cysteine protease a |
| Swissprot | |
| Calculated MW | 32 kDa |
| Observed MW | 20 kDa |
| Cellular Localization | Cytoplasm. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Neuroscience |
| Conjugation | Unconjugated |
| Background | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. |
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