Cleaved-PARP1 (D214) Polyclonal Antibody
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- 宿主： Rabbit
- 反应性： Human;Mouse
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB: A549 Verified Samples in IHC: Human lung cancer Verified Samples in IF: Rat spleen |
| Dilution | WB 1:500-2000, IHC 1:50-300, IF 1:50-300 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the Internal region of human PARP-1 |
| Abbre | Cleaved-PARP1 (D214) |
| Synonyms | ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT, ADPRT 1, ADPRT1, APOPAIN, ARTD1, NAD(+) ADP-ribosyltransferase 1, PARP, PARP-1, PARP1, PPOL, Poly ADP ribose polymerase 1, Poly [ADP-ribose] polymerase 1, Poly[ADP-ribose] synthase 1, SCA1 |
| Swissprot | |
| Calculated MW | 113 kDa |
| Observed MW | 24 kDa |
| Cellular Localization | Nucleus. Nucleus, nucleolus. Localizes at sites of DNA damage. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism |
| Conjugation | Unconjugated |
| Background | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. |
