CYCS Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC;IF
Verified Samples |
Verified Samples in WB: Hela, HepG2, Mouse lung, Mouse brain, Rat brain Verified Samples in IHC: Human lung cancer, Human heart Verified Samples in IF: Mouse kidney, Mouse liver |
Dilution | WB 1:500-1:2000, IHC 1:500-1:1000, IF 1:200-1:800 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Cytochrome c |
Abbre | CYCS |
Synonyms | Somatic, CYC, Cytochrome C, HCS., THC4 |
Swissprot | |
Calculated MW | 12 kDa |
Observed MW | 12 kDa |
Cellular Localization | Mitochondrion |
Concentration | 1.5 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4. |
Purification Method | Affinity purification |
Research Areas | Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction |
Conjugation | Unconjugated |
Background | Cytochrome c is a 12-15 kDa electron transporting protein located in the inner mitochondrial membrane. Upon apoptotic stimulation,cytochrome c can be released from mitochondria into cytoplasm,resulting in caspase-3 activation and apoptosis. Measurement of cytochrome c release from the mitochondria is useful for detection of the onset of apoptosis in cells. In addition,cytochrome c can also leave cells and be detectable in extra-cellular medium of apoptotic cells and serum of cancer patients. The level of serum cytochrome c may serve as a prognostic maker during cancer therapy. |
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