ERK 1/2 Polyclonal Antibody
Price:
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB: K562 Verified Samples in IHC: Human liver cancer Verified Samples in IF: Rat lung |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the C-terminal region of human ERK 1/2 |
| Abbre | ERK 1/2 |
| Synonyms | ERK-1, ERK1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, MAPK3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 3, PRKM3, p, p44-MAPK |
| Swissprot | |
| Calculated MW | 43 kDa |
| Observed MW | 42 ,44kDa |
| Cellular Localization | Nucleus. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction, Neuroscience |
| Conjugation | Unconjugated |
| Background | Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. |
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