LCN2 Polyclonal Antibody

Price:
- 宿主: Rabbit
- 反应性: Human;Mouse
- 应用性: WB;IF
Verified Samples |
Verified Samples in WB: DU145, HT29, BxPC-3, Mouse spleen Verified Samples in IF: Mouse kidney |
Dilution | WB 1:500-1:2000, IF 1:50-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant fusion protein of human LCN2 (NP_005555.2). |
Abbre | LCN2 |
Synonyms | 24p3, LCN2, MSFI, NGAL, p25 |
Swissprot | |
Calculated MW | 22 kDa |
Observed MW | 22 kDa |
Cellular Localization | Secreted. Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
Purification Method | Affinity purification |
Research Areas | Cancer, Cardiovascular, Metabolism, Immunology, Signal Transduction |
Conjugation | Unconjugated |
Background | This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. |