LMNA Polyclonal Antibody-Elabscience伊莱瑞特【官网】

LMNA Polyclonal Antibody

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货号：E-AB-31899
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说明书

说明书

Price: ¥2365.00 ¥1640.00 ¥1010.00 ¥420.00

Size:

200 μL 120 μL 60 μL 20 μL

宿主： Rabbit
反应性： Human;Mouse;Rat
应用性： WB;IHC-p;IF

Verified Samples	Verified Samples in WB: 3T3 Verified Samples in IHC: Human uterus Verified Samples in IF: Human liver
Dilution	WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000
Clonality	Polyclonal
Isotype	IgG
Immunogen	Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of Ser392.
Abbre	Lamin A/C
Synonyms	70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, Cardiomyopathy dilated 1A (autosomal dominant), EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN 1, LMN A, Lamin, Lamin A, Lamin A/C, Lamin A/C like 1, Lamin C, Lamin-A/C, Limb girdle muscular dystrophy 1B (autosomal dominant)
Swissprot	P02545
Calculated MW	74 kDa
Observed MW	74 kDa,65kDa
Cellular Localization	Nucleus. Nucleus envelope. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4.
Purification Method	Affinity purification
Research Areas	Cancer, Signal Transduction, Tags and Cell Markers
Conjugation	Unconjugated
Background	The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants.

Western Blot analysis of 3T3 cells using LMNA Polyclonal Antibody at dilution of 1:2000.

Immunohistochemistry of paraffin-embedded Human uterus tissue using LMNA Polyclonal Antibody at dilution of 1:200.

Immunofluorescence analysis of Human liver tissue using LMNA Polyclonal Antibody at dilution of 1:200.

Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis

IF: 4.315

Journal： CELLULAR SIGNALLING (2021)

DOI：10.1016/j.cellsig.2021.109928

PMID：33482299

Reactivity：Human

Sample Type：Cell sample

E-AB-1003	Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1010	Goat Anti-Rabbit IgG(H+L)(Cyanine3 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1014	Goat Anti-Rabbit IgG(H+L)(FITC conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1060	Goat Anti-Rabbit IgG(H+L)(Elab Fluor® 594 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1075	Goat Anti-Rabbit IgG(H+L)(Elab Fluor® 647 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1099	Elab Fluor® Violet 450-Goat Anti-Rabbit IgG(H+L)	500 μL , 120 μL , 1 mL
E-AB-1194	HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10mL , 3mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10mL , 3mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays