mTOR Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: IHC;IF
Verified Samples |
Verified Samples in IHC: Rat ovary, Human tonsil, Human liver cancer, Human placenta, Mouse liver, Mouse kidney Verified Samples in IF: HeLa, NIH/3T3, PC12 |
Dilution | IHC 1:50-1:200, IF 1:50-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant fusion protein of human mTOR (NP_004949.1). |
Abbre | mTOR |
Synonyms | FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1, SKS, mTOR |
Swissprot | |
Cellular Localization | Endoplasmic reticulum membrane. Golgi apparatus membrane. Mitochondrion outer membrane. Lysosome. Cytoplasm. Nucleus>PML body. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
Purification Method | Affinity purification |
Research Areas | Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism |
Conjugation | Unconjugated |
Background | The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. |
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Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities
IF: 3.800Journal: Chinese Herbal Medicines (2023)Reactivity:RatSample Type:heart tissue -
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)
IF: 4.219Journal: TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)PMID:34933056Reactivity:RatSample Type:testis tissue -
Effect of PI3K/Akt/mTOR signaling pathway on JNK3 in Parkinsonian rats
IF: 1.410Journal: Experimental and Therapeutic Medicine (2018)PMID:30783448Reactivity:ratSample Type:Tissue homogenate