Phospho-CREB1 (Ser133) Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC-p;IF
Verified Samples |
Verified Samples in WB: MCF-7, A549, K562, HEK293 Verified Samples in IHC: Human uterus Verified Samples in IF: Mouse lung |
Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Synthesized peptide derived from human CREB-1 around the phosphorylation site of Ser133 |
Abbre | CREB-1 (phospho Ser133) |
Synonyms | Active transcription factor CREB, CREB, CREB-1, CREB1, Cyclic AMP-responsive element-bindin, cAMP response element binding protein, cAMP response element binding protein 1, cAMP responsive element binding protein 1, cAMP-responsive element-binding protein 1 |
Swissprot | |
Calculated MW | 37 kDa |
Observed MW | 37 kDa |
Cellular Localization | Nucleus. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
Purification Method | Affinity purification |
Research Areas | Cancer, Epigenetics and Nuclear Signaling, Immunology |
Conjugation | Unconjugated |
Background | This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity. |
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