Phospho-IkB alpha (Ser32/S36) Polyclonal Antibody
Price:
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat;Monkey
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB: COS-7 Verified Samples in IHC: Mouse kidney Verified Samples in IF: Rat spleen |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human IκB-α around the phosphorylation site of Ser32/36 |
| Abbre | IκB-α (phospho Ser32/36) |
| Synonyms | I kappa B alpha, I-kappa-B-alpha, IKBA, IKBalpha, IkB-alpha, IkappaBalpha, MAD 3, MAD3, Major histocompatibility complex enhancer-binding protein MAD3, NF kappa B inhibitor alpha, NF-kappa-B inhibitor alpha, NFKBI, NFKBIA, Nuclear factor of kappa light chain gene |
| Swissprot | |
| Calculated MW | 36 kDa |
| Observed MW | 34 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Background | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
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