PKC zeta Polyclonal Antibody
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- 宿主： Rabbit
- 反应性： Human;Mouse;Rat;Monkey
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB: COS-7 |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human PKC ζ around the non-phosphorylation site of Thr560. |
| Abbre | PKC ζ |
| Synonyms | 14-3-3-zetaisoform, AI098070, C80388, EC 2.7.11.13, KPCZ, OTTHUMP00000001368, OTTHUMP00000044160, PKC 2, PKC ZETA, PKC2, PKCZETA, PKM-zeta, PRKCZ, Pkcz, Protein kinase C zeta, Protein kinase C zeta form, Protein kinase C zeta type, aPKCzeta, included, nPKC zeta, nPKC-zeta, r1 |
| Swissprot | |
| Calculated MW | 68 kDa |
| Observed MW | 80 kDa |
| Cellular Localization | Cytoplasm. Endosome. Cell junction. In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Background | This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Phosphorylates 'Ser-311' of RELA subunit of NF-kappa-B.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization. |
