TH Polyclonal Antibody（E-AB-70077）|-Elabscience伊莱瑞特【官网】

TH Polyclonal Antibody

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货号：E-AB-70077
文献（18）
说明书

说明书

Price: ¥3300.00 ¥2220.00 ¥1380.00

Size:

200 μL 120 μL 60 μL

宿主： Rabbit
反应性： Human;Mouse;Rat
应用性： WB;IHC;IF

Verified Samples	Verified Samples in WB: U251, N2A, C6 Verified Samples in IHC: Mouse brain striatum, Rat brain striatum, Mouse brain
Dilution	WB 1:500-1:2000, IHC 1:300-1:800, IF 1:200-1:800
Clonality	Polyclonal
Isotype	IgG
Immunogen	Recombinant protein corresponding to Mouse Tyrosine Hydroxylase
Abbre	TH
Synonyms	DYT14, DYT5b, Dystonia 14, EC 1.14.16.2, OTTHUMP00000011225, OTTHUMP00000011226, Protein Pale, TH, TY3H, TYH, The, Tyrosine 3 hydroxylase, Tyrosine 3 monooxygenase, Tyrosine 3-hydroxylase, Tyrosine 3-monooxygenase, Tyrosine hydroxylase, ple
Swissprot	P24529, P04177
Calculated MW	62 kDa
Observed MW	62 kDa
Cellular Localization	Cytosol, Endoplasmic reticulum, smooth endoplasmic reticulum, Mitochondrion, Nucleus, Plasma Membrane, cytoplasmic side of plasma membrane, Other locations: cytoplasm, cytoplasmic vesicle, dendrite, melanosome membrane, neuron projection, perikaryon, synaptic vesicle, terminal bouton.
Concentration	370 μg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.
Purification Method	Affinity purification
Research Areas	Cancer, Metabolism, Neuroscience
Conjugation	Unconjugated
Background	TH(Tyrosine 3-monooxygenase) converts L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA),the essential and rate-limiting step to formation of dopamine and other catecholamines. TH plays an important role in the physiology of adrenergic neurons and can be used as a marker for dopaminergic and noradrenergic neurons.

Western Blot analysis of various samples using TH Polyclonal Antibody at dilution of 1:1000.

Immunohistochemistry analysis of paraffin-embedded Mouse brain striatum using TH Polyclonal Antibody at dilution of 1:300.

Immunohistochemistry analysis of paraffin-embedded Rat brain striatum using TH Polyclonal Antibody at dilution of 1:300.

Immunofluorescence analysis of paraffin-embedded mouse brain using TH Polyclonal Antibody at dilution of 1:300.

Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone-induced mice model of Parkinson's disease: Role of executioner caspase-3/Nrf2/ARE signaling

IF: 3.654

Journal： JOURNAL OF FOOD BIOCHEMISTRY (2022)

DOI：10.1111/jfbc.14253

PMID：35608987

Reactivity：Mouse

Sample Type：brain
Morin ameliorates rotenone-induced Parkinson disease in mice through antioxidation and anti-neuroinflammation: gut-brain axis involvement

IF: 3.610

Journal： BRAIN RESEARCH (2022)

DOI：10.1016/j.brainres.2022.147958

PMID：35654119

Reactivity：Mouse

Sample Type：brain
Probiotic Enhancement of Antioxidant Capacity and Alterations of Gut Microbiota Composition in 6-Hydroxydopamin-Induced Parkinson’s Disease Rats

IF: 6.313

Journal： Antioxidants (2021)

DOI：10.3390/antiox10111823

Reactivity：Rat

Sample Type：striatum tissue,substantia nigra pars compacta (SNpc) tissue
Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

IF: 5.750

Journal： Frontiers in Aging Neuroscience (2021)

DOI：10.3389/fnagi.2021.668775

Reactivity：Rat

Sample Type：striatum tissue,SNc pars compacta (SNc) tissue
Kolaviron protects against nigrostriatal degeneration and gut oxidative damage in a stereotaxic rotenone model of Parkinson’s disease

IF: 3.130

Journal： PSYCHOPHARMACOLOGY (2020)

DOI：10.1007/s00213-020-05605-w

PMID：32651640

Reactivity：Rat

Sample Type：Tissue homogenate
Idebenone Ameliorates Rotenone-Induced Parkinson’s Disease in Rats Through Decreasing Lipid Peroxidation

IF: 3.038

Journal： NEUROCHEMICAL RESEARCH (2020)

DOI：10.1007/s11064-020-03186-w

PMID：33247801

Reactivity：Rat

Sample Type：brain
Neuroprotective action of agmatine in rotenone-induced model of Parkinson’s disease: Role of BDNF/cREB and ERK pathway

IF: 2.977

Journal： BEHAVIOURAL BRAIN RESEARCH (2020)

DOI：10.1016/j.bbr.2020.112692

PMID：32479847

Reactivity：Rat

Sample Type：Tissue
The neuroprotective action of lenalidomide on rotenone model of Parkinson's Disease: Neurotrophic and supportive actions in the substantia nigra pars compacta

IF: 2.274

Journal： NEUROSCIENCE LETTERS (2020)

DOI：10.1016/j.neulet.2020.135308

PMID：32932183

Reactivity：Rat

Sample Type：Tissue homogenate

E-AB-1003	Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1010	Goat Anti-Rabbit IgG(H+L)(Cyanine3 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1014	Goat Anti-Rabbit IgG(H+L)(FITC conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043	Streptavidin(peroxidase/HRP conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1060	Goat Anti-Rabbit IgG(H+L)(Elab Fluor® 594 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1075	Goat Anti-Rabbit IgG(H+L)(Elab Fluor® 647 conjugated)	500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1099	Elab Fluor® Violet 450-Goat Anti-Rabbit IgG(H+L)	500 μL , 120 μL , 1 mL
E-AB-1194	HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed	500 μL , 120 μL , 1 mL
E-IR-R217	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)	50 mL , 18 mL , 6 mL , 3 mL
E-IR-R220	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0)	10 mL , 3 mL
E-IR-R221	Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0)	10 mL , 3 mL
E-IR-R304A	Western Blot Detection Kit	50 Assays
E-IR-R304B	High Accuracy and Absorbability Western Blot Detection Kit	50 Assays